蛋白质聚集（Protein Aggregation）是蛋白因错误折叠而导致构象发生变化形成聚集，使蛋白失活，在生物技术和制药领域，这些聚集会严重影响蛋白的生产和应用，是蛋白类药物研发和商业化过程中一个重要的挑战之一。聚集体在蛋白质产品开发和生产过程的所有阶段都可以观察到，如蛋白表达、纯化、冻干等。此外蛋白聚集体可能存在潜在增强免疫原性的风险。生物制药行业一直都希望在生物工艺中找到新的方法，可用于检测、追踪、定量分析影响蛋白聚集的因素。

如何准确高效地定量分析生物制品中的蛋白质聚集情况呢？作为专业的生命科学医药原料供应商，kok登录入口 科技为您推荐Enzo Life Sciences（Enzo）荣誉出品，PROTEOSTAT Protein aggregation assay（ENZ-51023）

*** 该产品仅用于科研实验.

PROTEOSTAT Protein aggregation assay

提供了一种可靠、简便、精确的测定方法，用于监测溶液中的肽和蛋白质聚集情况。

*PROTEOSTAT 蛋白质聚集标准品（ENZ-51039）是wei一可商用的检测痕量蛋白质聚集体水平的稳定、高质量标准品。易于使用 -只需加水！

蛋白质聚集检测试剂盒，特点：

• 一种简单、敏感、均匀的荧光检测方法

• 经过验证可用于微板或流式细胞仪平台

• 以IgG为基准进行了广泛的测试

• 优化蛋白质配方的缓冲剂和辅料

• 在广泛的pH值和离子强度范围内表现良好

• 与PROTEOSTAT蛋白质聚集标准品一起使用，可精确定量溶液中的聚集蛋白。

蛋白质聚集检测试剂盒，应用：

• 鉴别蛋白聚集抑制剂

• 监控大包装产品和反复冻融引起的蛋白聚集

• 确定病毒灭活后的储存条件

• 优化蛋白制剂中缓冲液和赋形剂的配方

• 确定纯化后的储存条件

蛋白质聚集检测试剂盒，结果展示：

相关产品推荐：

PROTEOSTAT 蛋白质聚集检测试剂盒，ENZ-51023发表文章

• Cell-Instructive Surface Gradients of Photoresponsive Amyloid-like Fibrils: A.M. Bender, et al.; ACS Biomater. Sci. Eng. 7, 4798 (2021), Abstract;

• Characterization of Protein Aggregates, Silicone Oil Droplets, and Protein-Silicone Interactions using Imaging Flow Cytometry: C. Probst; J. Pharm. Sci. 109, 364 (2020), Abstract;

• Endoplasmic reticulum chaperone calmegin is upregulated in aldosterone-producing adenoma and associates with aldosterone production: K. Itcho, et al.; Hypertension 75, 492 (2020), Abstract;

• Monitoring plasma protein aggregation during aging using conformation-specific antibodies and FTIR spectroscopy: S. Magalhaes, et al.; Clin. Chim. Acta 502, 25 (2020), Application(s): Protein aggregation in human plasma samples, Abstract;

• PERK participates in cardiac valve development via fatty acid oxidation and endocardial-mesenchymal transformation: T. Shimizu, et al.; Sci. Rep. 10, 20094 (2020), Abstract; Full Text

• The polyphenol quercetin protects from glucotoxicity depending on the aggresome in Caenorhabditis elegans: M. Civelek, et al.; Eur. J. Nutr. 59, 485 (2020), Application(s): Protein aggregation in solution, Abstract;

• Fibril formation and therapeutic targeting of amyloid-like structures in a yeast model of adenine accumulation: D. Laor, et al.; Nat. Commun. 10, 62 (2019), Abstract; Full Text

• Transthyretin amyloid fibril disrupting activities of extracts and fractions from Juglans mandshurica maxim. var. cordiformis (Makino) kitam: N. Chaudhary, et al.; Molecules 24, 500 (2019), Application(s): Aged amyloid fibrils, Abstract; Full Text

• Caffeic acid and resveratrol ameliorate cellular damage in cell and Drosophila models of spinocerebellar ataxia type 3 through upregulation of Nrf2 pathway: Y.L. Wu, et al.; Free Radic. Biol. Med. 115, 309 (2018), Abstract;

• Discovering putative prion-like proteins in Plasmodium falciparum: A computational and experimental analysis: I. Pallares, et al.; Front. Microbiol. 9, 1737 (2018), Application(s): P. falciparum culture, Abstract; Full Text

• High Throughput Differential Scanning Fluorimetry (DSF) Formulation Screening with Complementary Dyes to Assess Protein Unfolding and Aggregation in Presence of Surfactants: S.M. McClure, et al.; Pharm. Res. 35, 81 (2018), Abstract;

• The catalytic inactivation of the N-half of human hexokinase 2 and structural and biochemical characterization of its mitochondrial conformation: M.H. Nawaz, et al.; BioSci. Rep. 38, BSR20171666 (2018), Application(s): Aggregation propensity assessed by DSF, Abstract; Full Text

• Aggregated transthyretin is specifically packaged into placental nano-vesicles in preeclampsia: M. Tong, et al.; Sci. Rep. 7, 6694 (2017), Application(s): Protein aggregation in extracts from placental extracellular vesicles, Abstract; Full Text

• Curcumin Improves Palmitate-Induced Insulin Resistance in Human Umbilical Vein Endothelial Cells by Maintaining Proteostasis in Endoplasmic Reticulum: M. Ye, et al.; Front. Pharmacol. 8, 148 (2017), Abstract; Full Text

• Scaffold requirements for periodontal regeneration with enamel matrix derivative proteins: A. Apicella, et al.; Colloids Surf. B Biointerfaces 156, 221 (2017), Application(s): Aggregation of enaml matrix derivative (EMD) proteins, Abstract;

• Trans ε-viniferin is an amyloid-β disaggregating and anti-inflammatory drug in a mouse primary cellular model of Alzheimer's disease: E. Vion, et al.; Mol. Cell. Neurosci. 88, 1 (2017), Abstract;

• ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation: J.H. Seo, et al.; Nat. Commun. 7, 12882 (2016), Application(s): , Abstract; Full Text

• BRG1 and BRM SWI/SNF ATPases redundantly maintain cardiomyocyte homeostasis by regulating cardiomyocyte mitophagy and mitochondrial dynamics in vivo: S.J. Bultman, et al.; Cardiovasc. Pathol. 25, 258 (2016), Abstract;

• Cardiomyocyte-specific human Bcl2-associated anthanogene 3 P209L expression induces mitochondrial fragmentation, Bcl2-associated anthanogene 3: M.T. Quintana, et al.; Am. J. Pathol. 186, 1989 (2016), Application(s): Lysates from cardiac tissues, Abstract; Full Text

• Interfacial dilatational deformation accelerates particle formation in monoclonal antibody solutions: G.L. Lin, et al.; Soft Matter 12, 3293 (2016), Abstract;

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